IFN-Mediated ISGylation of HCV-NS5A Inhibition of Hepatitis C Virus Replication by
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منابع مشابه
Inhibition of hepatitis C virus replication by IFN-mediated ISGylation of HCV-NS5A.
ISG15 is a ubiquitin-like molecule whose expression is induced by type I IFN (IFN-α/β) or in response to virus or bacterial infection. ISG15 or conjugation of ISG15 to target proteins was reported to play critical roles in the regulation of antiviral responses. IFN restricts replication of hepatitis C virus (HCV). However, molecular mechanism of IFN-α/β that inhibits HCV replication is not clea...
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